Adobe Reader 11 and Internet Explorer locally installed on the Windows 7 64bit machine.

Used App-V to create the virtual application.

Added the following registry keys to make sure the local webserver is a secure source for the PDF documents and added the EULA key to make sure Adobe Reader does not come up with the message:

windows cannot find 'C:\Program Files (x86)\Internet Explorer\Eula.exe'

Windows Registry Editor Version 5.00

;<PFNAME>Adobe EULA & TrustManager settings</PFNAME>
;<PFDESC>Forcing EULA & adding localhost and 127.0.0.1 to the secure sources in Adobe Reader - MDuiker</PFDESC>

[HKEY_CURRENT_USER\]
@=""

[HKEY_CURRENT_USER\Software]
@=""

[HKEY_CURRENT_USER\Software\Adobe]
@=""

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader]
@=""

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0]
@=""

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager]
@=""

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites]
@=""

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cAlwaysTrustedForJavaScript]
@=""
"t8"="localhost"
"t21"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cCrossdomain]
@=""
"t2"="localhost"
"t15"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cDataInjection]
@=""
"t6"="localhost"
"t19"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cExternalStream]
@=""
"t3"="localhost"
"t16"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cFileAttachment]
@=""
"t10"="localhost"
"t23"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cJavaScript]
@=""
"t4"="localhost"
"t17"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cJavaScriptURL]
@=""
"t9"="localhost"
"t22"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cMultiMedia]
@=""
"t11"="localhost"
"t24"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cScriptInjection]
@=""
"t5"="localhost"
"t18"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cSilentPrint]
@=""
"t1"="localhost"
"t14"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cTrustedForPV]
@=""
"t12"="localhost"
"t25"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\TrustManager\cTrustedSites\cUnsafeJavaScript]
@=""
"t7"="localhost"
"t20"="127.0.0.1"

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\11.0\AdobeViewer]
@=""
"EULA"=dword:00000001