There is an article on the SPSS Support site (Resolution number 55630) thats says Users "will need at least Read, Write, and Execute permission for the MySQL for version 1.5 or the MSDE for version 2.0 and STAfS directories." I run in a locked down environment, so that didn't make me happy! So far I have confirmed that just to run the program, users must be able to write to file.lock and jvm.args - I'm sure there will be more!
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