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Internet Security error when running RegEdit within App-V

I have published my APP-V package on a machine but when I try to run regedit.exe inside the APP-V bubble, it gives me the error pop-up "These files can't be opened. Your Internet security settings prevented one or more files from being opened."

I am getting error message as shown below :
these files cannot be opened.

Note : This happens when I try to run any executable inside the bubble.

Please help me find out a solution.

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