Using Wise Package Studio, captured the Mozilla installer, selecting the desired options. Made adjustments to the Start Menu and install directory to mesh with corporate standards, removed the files captured in the installing account's directory, removed profile-specific INIs. Compiled into an MSI and was able to distribute via Active Directory.
I'd like to add to the above, that without any fancy customization you can set all of the default settings by launching "firefox -p" from a command line, creating a new profile located at %PROGRAMFILES%\Mozilla Firefox\defaults\profile, and then copying that profile down to a machine in the same location just after install. This will force firefox to copy your customized profile as the template whenever firefox is launched for the first time.
I used the Firefox Add-on Maker to make a custom exe build of Firefox that would install silently and not have shortcuts (there are a lot more options available), download at http://sourceforge.net/projects/firefoxaddonmak/files/
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