Rebooting of machine is essential after installation and un-installation of the application. It is strictly recommended not to launch application before rebooting of machine after installation or un-installation, It can also hang user machine.
Another option (if you're using MDT) is to extract the files from the IE8-WindowsVista-x86-ENU.exe file. This gives you four new files: eula, ie8, iesetup, sqmapi.dll. The extracted IE8.msu can then be imported as an OS package in the deployment share.
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